Acute kidney injury due to sucrose-containing intravenous immunoglobulins

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Intravenous immunoglobulins: in-depth review of excipients and acute kidney injury risk.

BACKGROUND Used in a variety of approved and off-label indications, there are several intravenous immunoglobulin (IVIG) preparations available which differ in the excipients (e.g. sucrose, glucose, maltose, D-sorbitol, glycine or L-proline) used to stabilize the protein in the solution. A very rare, but severe adverse drug reaction (ADR) reported with sucrose-stabilized IVIGs, acute renal failu...

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Intravenous Immunoglobulins: In-Depth Review of Excipients and Acute Kidney Injury Risk

Background: Used in a variety of approved and off-label indications, there are several intravenous immunoglobulin (IVIG) preparations available which differ in the excipients (e.g. sucrose, glucose, maltose, D -sorbitol, glycine or L -proline) used to stabilize the protein in the solution. A very rare, but severe adverse drug reaction (ADR) reported with sucrose-stabilized IVIGs, acute renal fa...

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ژورنال

عنوان ژورنال: Saudi Journal of Kidney Diseases and Transplantation

سال: 2019

ISSN: 1319-2442

DOI: 10.4103/1319-2442.261361